Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRVMA5)

Drug Name

NSC-66811 Drug Info

Synonyms

NSC 66811; 6964-62-1; NSC-66811; 2-METHYL-7-[PHENYL(PHENYLAMINO)METHYL]-8-QUINOLINOL; 7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol; 7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol; 2-methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol; 8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline; NSC66811; AC1L6NIN; AC1Q79MP; 7-(anilino(phenyl)methyl)-2-methyl-8-quinolinol; SCHEMBL1241576; CHEMBL210778; BDBM31206; CTK5D0724; DTXSID30290119; MolPort-008-431-978; BCP07490; 2152AH; AKOS003020553; AKOS016050521; AK260645; M2390

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 248986
CAS Number: CAS 6964-62-1
TTD Drug ID: DMRVMA5

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Mdm2 messenger RNA (MDM2 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NUTLIN-3	DM5KXFI	Discovery agent	N.A.	Investigative	[2]
NU-8231	DMEUV5R	Discovery agent	N.A.	Investigative	[3]
ISIS 16518	DM24L0S	Solid tumour/cancer	2A00-2F9Z	Investigative	[4]
PLSQETFSDLWKLLPEN-NH2	DMBN4V6	Discovery agent	N.A.	Investigative	[5]
ISIS 16507	DMK69ZR	Solid tumour/cancer	2A00-2F9Z	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mdm2 messenger RNA (MDM2 mRNA)	TT9TE0O	MDM2_HUMAN	Inhibitor	[1]

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References

1	Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening str... J Med Chem. 2006 Jun 29;49(13):3759-62.
2	Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature. 2007 Dec 13;450(7172):1001-9.
3	Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. J Med Chem. 2006 Oct 19;49(21):6209-21.
4	US patent application no. 6,238,921, Antisense oligonucleotide modulation of human mdm2 expression.
5	Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. J Med Chem. 2006 Jun 15;49(12):3432-5.