Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS3HNM)

Drug Name

Jte 013 Drug Info

Synonyms

Jte 013; JTE-013; 383150-41-2; CHEMBL1368758; S1P2 Receptor Antagonist, JTE-013; N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide; 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea; 1-(1,3-Dimethyl-4-isopropyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)-4-(3,5-dichloro-4-pyridinyl)-semicarbazide; pyrazolopyridine analog; C17H19Cl2N7O; GTPL2917; SCHEMBL5911940; CHEBI:92763; CTK8F0047; SYN5010; DTXSID60436982; AOB1935; HMS3650O12;

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10223146
ChEBI ID: CHEBI:92763
CAS Number: CAS 383150-41-2
TTD Drug ID: DMS3HNM

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Sphingosine-1-phosphate receptor 2 (S1PR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiselimod	DMI7CYZ	Ulcerative colitis	DD71	Phase 2	[3]
US8975409, Example 13	DMVB42P	N. A.	N. A.	Patented	[4]
SCHEMBL15295829	DMK0T9E	N. A.	N. A.	Patented	[2]
US8975409, Example 9(3)	DMJQOAE	N. A.	N. A.	Patented	[4]
Unii-R228S06soh	DMUHSAZ	N. A.	N. A.	Patented	[2]
US8975409, Comparative compound B	DM4S5DF	N. A.	N. A.	Patented	[4]
AUY954	DMVGIO5	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sphingosine-1-phosphate receptor 2 (S1PR2)	TTVSMOH	S1PR2_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2917).
2	Sphingosine 1-phosphate receptor antagonists. US9663511.
3	Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk. Br J Pharmacol. 2017 Jan;174(1):15-27.
4	Phenyl derivative. US8975409.
5	A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006 Nov;13(11):1227-34.