Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS3TZ5)

Drug Name

XD1 Drug Info

Synonyms

colchicein; colchiceine; NSC33411

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Bromodomain-containing protein 4 (BRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CPI-0610	DMPXOYJ	Myelofibrosis	2A20.2	Phase 3	[3]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[3]
PLX2853	DMX168L	Acute myeloid leukaemia	2A60	Phase 1/2	[4]
RVX-208	DM1LO8K	Alzheimer disease	8A20	Phase 1/2	[3]
INCB57643	DMBGU7V	Advanced malignancy	2A00-2F9Z	Phase 1/2	[4]
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[4]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[5]
GSK525762	DMPAWBN	Haematological malignancy	2B33.Y	Phase 1	[3]
TEN010	DM4UOY5	Advanced solid tumour	2A00-2F9Z	Phase 1	[3]
AZD5153	DMW4GM2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain-containing protein 4 (BRD4)	TTRA6BO	BRD4_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7525).
2	4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9.
3	Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.