Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS4ZVK)

Drug Name
(Amino-phenyl-methyl)-phosphinic acid Drug Info
Synonyms
Phosphinic acid, (aminophenylmethyl)-; 126529-62-2; 1-amino-1-phenylmethylphosphinic acid; ACMC-20ms0y; AC1O46MZ; SCHEMBL1764684; CTK0F6605; (aminophenylmethyl)phosphinic acid; DTXSID00422960; JLTNHFQJNQZJTC-UHFFFAOYSA-N
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
57013015
TTD Drug ID
DMS4ZVK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Aminopeptidase N (ANPEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
IP10 C8 DMANRGW Psoriasis vulgaris EA90 Phase 2 [2]
[(125)I] RB129 DMX0G7E Discovery agent N.A. Investigative [3]
KELATORPHAN DMOX8FD Discovery agent N.A. Investigative [4]
(1-Amino-3-phenyl-propyl)-phosphinic acid DMXD697 Discovery agent N.A. Investigative [1]
N1-(3,3-diphenylpropyl)-N3-hydroxymalonamide DM5F04D Discovery agent N.A. Investigative [5]
N1-(4-chlorobenzyl)-2-benzyl-N3-hydroxymalonamide DMTMDZ4 Discovery agent N.A. Investigative [5]
N1,2-dibenzyl-N3-hydroxy-N1-phenethylmalonamide DM1L89K Discovery agent N.A. Investigative [5]
1-aminohexylphosphonic acid DMFUABI Discovery agent N.A. Investigative [6]
(S)-2-Amino-3-phenyl-propane-1-thiol DMMAUKO Discovery agent N.A. Investigative [1]
1-aminohexylphosphonic acid monophenyl ester DML6UJM Discovery agent N.A. Investigative [6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aminopeptidase N (ANPEP) TTPHMWB AMPN_HUMAN Inhibitor [1]

References

1 Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6.
2 Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions. Clin Chem Lab Med. 2009;47(3):253-61.
3 Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography. Biochimie. 2004 Feb;86(2):105-13.
4 Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. J Med Chem. 1988 Sep;31(9):1825-31.
5 Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34.
6 New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2010 Apr 15;18(8):2930-6.