Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS5OL0)

Drug Name

CD56 CAR T cells Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Multiple myeloma	2A83	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Neural cell adhesion molecule 1 (NCAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CD56-specific gene-engineered T cells	DM35XCT	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
CART-56 cells	DMQTOBF	Acute myeloid leukaemia	2A60	Phase 1	[3]
CAR-T cells targeting CD56	DMAK1ME	Multiple myeloma	2A83	Clinical trial	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neural cell adhesion molecule 1 (NCAM1)	TTVXPHT	NCAM1_HUMAN	CAR-T-Cell-Therapy	[1]

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References

1	ClinicalTrials.gov (NCT03271632) Multi-CAR T Cell Therapy in the Treatment of Multiple Myeloma
2	ClinicalTrials.gov (NCT03222674) Multi-CAR T Cell Therapy for Acute Myeloid Leukemia
3	ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS
4	ClinicalTrials.gov (NCT03473457) CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia