Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS9KCF)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Preclinical Drug(s)

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Drug(s) Targeting Herpesvirus ubiquitin-specific protease (HAUSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID26077642-Compound-Vif2	DMYXIS7	N. A.	N. A.	Patented	[1]
ADC-03	DM21I35	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
P22077	DMD8JIC	Inflammation	1A00-CA43.1	Preclinical	[3]
HBX19818	DM6GSI1	Solid tumour/cancer	2A00-2F9Z	Preclinical	[4]
ADC-01	DM19R28	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
P5091	DMGIR3F	Solid tumour/cancer	2A00-2F9Z	Preclinical	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Herpesvirus ubiquitin-specific protease (HAUSP)	TTXU3EQ	UBP7_HUMAN	Inhibitor	[1]

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References

1	Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208.
2	Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics. Cancers (Basel). 2020 Jun 15;12(6):1579.
3	P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6. Aging (Albany NY). 2020 Jun 9;12(11):10969-10982.
4	Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug;8(8):2286-95.
5	USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth. Biochem Pharmacol. 2017 May 1;131:29-39.