Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSC7TN)

Drug Name

Rimacalib Drug Info

Synonyms

SMP-114

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting CaM-kinase II (CAMK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABIO 09-01	DM0LUOM	Anxiety disorder	6B00-6B0Z	Investigative	[3]
PMID18337095C27	DMEOHLV	Discovery agent	N.A.	Investigative	[4]
PMID18334293C15b	DM1I6AY	Discovery agent	N.A.	Investigative	[5]
KN-93	DMPTMKH	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
CaM-kinase II (CAMK2)	TTFYL58	KCC2A_HUMAN; KCC2B_HUMAN; KCC2D_HUMAN; KCC2G_HUMAN	Modulator	[2]

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References

1	CaMKII inhibitors: from research tools to therapeutic agents. Front Pharmacol. 2014; 5: 21.
2	Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts. Ann N Y Acad Sci. 2009 Sep;1173:706-11.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1558).
4	Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 3: Importance of the indole orientation. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2399-403.
5	Pyrimidine-based inhibitors of CaMKIIdelta. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2404-8.
6	Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound. J Med Chem. 2002 Jan 31;45(3):563-6.