Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSCR2H)

• Drug Name: Cerdulatinib Drug Info
• Synonyms: PRT-062070; Syk + JAK multikinase inhibitor (NHL/CLL/RA), Portola Pharmaceuticals

Indication

Disease Entry	ICD 11	Status	REF
B-cell lymphoma	2A86	Phase 2	[1]
Non-hodgkin lymphoma	2B33.5	Phase 1/2	[2]
Atopic dermatitis	EA80	Phase 1	[3]
Vitiligo	ED63.0	Phase 1	[3]

• Cross-matching ID:
  PubChem CID: 44595079
  CAS Number: CAS 1198300-79-6
  TTD Drug ID: DMSCR2H

Molecule-Related Drug Atlas

Drug(s) Targeting Janus kinase 2 (JAK-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[5]
Baricitinib	DM4ONW5	Rheumatoid arthritis	FA20	Approved	[6]
Ruxolitinib	DM7Q98D	Essential thrombocythemia	3B63.1Z	Approved	[7]
Pacritinib	DM1T6ZN	Myelofibrosis	2A20.2	Approved	[8]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[9]
ITF2357	DMFZBNE	Duchenne dystrophy	8C70	Phase 3	[10]
XL019	DMJ6F5C	Solid tumour/cancer	2A00-2F9Z	Phase 3	[10]
CTP-543	DM3SYOK	Alopecia	ED70	Phase 2	[11]
INCB039110	DMD9RV3	Malignant neoplasm	2A00-2F9Z	Phase 2	[12]
CTP-543	DM3SYOK	Alopecia	ED70	Phase 2	[13]

Drug(s) Targeting Janus kinase 3 (JAK-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[14]
Ritlecitinib	DMYKNME	Alopecia areata	ED70.2	Approved	[3]
ASP-015K	DMZ1UOI	Psoriasis vulgaris	EA90	Phase 3	[15]
VX-509	DM2U3MX	Rheumatoid arthritis	FA20	Phase 2/3	[6]
ATI-501	DMTY6OF	Alopecia	ED70	Phase 2	[16]
ATI-502	DM8NODR	Alopecia	ED70	Phase 2	[17]
TD-8236	DMTOMJN	Asthma	CA23	Phase 2	[18]
ALXN2075	DM1BSD8	Non-hodgkin lymphoma	2B33.5	Phase 1/2	[19]
SNA-125	DM8L1GJ	Atopic dermatitis	EA80	Phase 1	[3]
GDC-0214	DMCNSII	Asthma	CA23	Phase 1	[20]

Drug(s) Targeting Tyrosine-protein kinase SYK (SYK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fostamatinib	DM6AUHV	Immune thrombocytopenic purpura	3B64.13	Approved	[21]
Fostamatinib disodium	DM3274D	Thrombocytopenia	3B64	Phase 3	[22]
TAK-659	DMJH3U0	Diffuse large B-cell lymphoma	2A81	Phase 2	[23]
GS-9876	DM9Q2B6	Cutaneous lupus erythematosus	EB5Z	Phase 2	[11]
GS-9973	DMKWCTR	Acute myeloid leukaemia	2A60	Phase 2	[24]
Cevidoplenib	DM9QU5G	Rheumatoid arthritis	FA20	Phase 2	[25]
HM43239	DMV1SDA	Acute myeloid leukaemia	2A60	Phase 1/2	[26]
ALXN2075	DM1BSD8	Non-hodgkin lymphoma	2B33.5	Phase 1/2	[19]
SKI-O-703	DMTSKXR	Rheumatoid arthritis	FA20	Phase 1	[11]
PRT6207	DMP5CLY	Solid tumour/cancer	2A00-2F9Z	Phase 1	[27]

Drug(s) Targeting Janus kinase 1 (JAK-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Baricitinib	DM4ONW5	Rheumatoid arthritis	FA20	Approved	[6]
Ruxolitinib	DM7Q98D	Essential thrombocythemia	3B63.1Z	Approved	[7]
Upadacitinib	DM32B5U	Rheumatoid arthritis	FA20	Approved	[28]
ASP-015K	DMZ1UOI	Psoriasis vulgaris	EA90	Phase 3	[29]
SHR0302	DMUL8ZT	Ulcerative colitis	DD71	Phase 3	[30]
CTP-543	DM3SYOK	Alopecia	ED70	Phase 2	[11]
INCB039110	DMD9RV3	Malignant neoplasm	2A00-2F9Z	Phase 2	[29]
PF-06700841	DMMGSFV	Asthma	CA23	Phase 2	[3]
ATI-501	DMTY6OF	Alopecia	ED70	Phase 2	[16]
ATI-502	DM8NODR	Alopecia	ED70	Phase 2	[17]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Janus kinase 1 (JAK-1)	TT6DM01	JAK1_HUMAN	Inhibitor	[3]
Janus kinase 2 (JAK-2)	TTRMX3V	JAK2_HUMAN	Modulator	[4]
Janus kinase 3 (JAK-3)	TTT7PJU	JAK3_HUMAN	Inhibitor	[3]
Tyrosine-protein kinase SYK (SYK)	TTOU65C	KSYK_HUMAN	Modulator	[4]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Clinical pipeline report, company report or official report of Portola.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Company report (Portola Pharmaceuticals)
• [5] Genetic determinants of response and survival in momelotinib-treated patients with myelofibrosis.Leukemia.2015 Mar;29(3):741-4.
• [6] Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77.
• [7] 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
• [8] National Cancer Institute Drug Dictionary (drug id 609888).
• [9] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [10] Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Sep;14(3):471-9.
• [11] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [12] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2048).
• [13] Clinical pipeline report, company report or official report of Concert Pharmaceuticals.
• [14] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [15] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2049).
• [16] Clinical pipeline report, company report or official report of Aclaris Therapeutics.
• [17] ClinicalTrials.gov (NCT03759340) ATI-502 Topical Solution for the Treatment of Alopecia Areata (AA), Alopecia Universalis (AU) and Alopecia Totalis (AT). U.S. National Institutes of Health.
• [18] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
• [19] The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2017 May 1;23(9):2313-2324.
• [20] Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A?randomized, controlled, proof-of-activity trial. J Allergy Clin Immunol. 2021 Sep;148(3):783-789.
• [21] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2230).
• [22] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [23] J Clin Oncol 32:5s, 2014 (suppl; abstr 8580).
• [24] An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2015 Apr 9;125(15):2336-43.
• [25] A novel selective spleen tyrosine kinase inhibitor SKI-O-703 (cevidoplenib) ameliorates lupus nephritis and serum-induced arthritis in murine models. Clin Exp Immunol. 2023 Mar 8;211(1):31-45.
• [26] Clinical pipeline report, company report or official report of Hanmi Pharmaceutical.
• [27] Advances in kinase inhibition: treating rheumatic diseases and beyond. Curr Opin Rheumatol. 2014 March; 26(2): 237-243.
• [28] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [29] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2047).
• [30] Efficacy and Safety of SHR0302, a Highly Selective Janus Kinase 1 Inhibitor, in Patients with Moderate to Severe Atopic Dermatitis: A Phase II Randomized Clinical Trial. Am J Clin Dermatol. 2021 Nov;22(6):877-889.