General Information of Drug (ID: DMSGNVK)

Drug Name
GSK2793660 Drug Info
Synonyms 2793660
Indication
Disease Entry ICD 11 Status REF
Bronchiectasis CA24 Phase 1 [1]
Cross-matching ID
PubChem CID
60144367
TTD Drug ID
DMSGNVK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BI 1291583 DMOZGBQ Non-cystic fibrosis bronchiectasis CA24 Phase 2 [2]
GNF-PF-5434 DMP9AIH Discovery agent N.A. Investigative [3]
PMID3941405C3d DM6ZOW4 Discovery agent N.A. Investigative [4]
(S)-2-amino-N-(1-cyano-2-phenylethyl)acetamide DMN1G8L Discovery agent N.A. Investigative [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dipeptidyl peptidase I (CTSC) TT4H0V2 CATC_HUMAN Modulator [1]

References

1 ClinicalTrials.gov (NCT02058407) A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Food Effect of Single or Repeat Doses of GSK2793660 in Healthy Subjects. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of boehringer-ingelheim
3 Substrate optimization for monitoring cathepsin C activity in live cells. Bioorg Med Chem. 2009 Feb 1;17(3):1064-70.
4 Carboxyl-modified amino acids and peptides as protease inhibitors. J Med Chem. 1986 Jan;29(1):104-11.
5 Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3614-7.