General Information of Drug (ID: DMSYOHD)

Drug Name
NN-dimethyl-D-erythrosphingosine Drug Info
Synonyms
N,N-DMS; UNII-L9QRA71834; C20H41NO2; L9QRA71834; 122314-67-4; 4-Octadecene-1,3-diol, 2-(dimethylamino)-, (S-(R*,S*-(E)))-; AC1O5P5P; GTPL2454; CHEMBL447685; ZINC43706449; 1710AH; LS-172527; N,N-Dimethylsphingosine, > =98.0% (TLC); (E,2R,3S)-2-dimethylaminooctadec-4-ene-1,3-diol; (E,2R,3S)-2-(dimethylamino)octadec-4-ene-1,3-diol; (2R,3S,E)-2-(dimethylamino)octadec-4-ene-1,3-diol; (e,2r,3s)-2-(dimethylamino)-octadec-4-ene-1,3-diol
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6438166
CAS Number
CAS 122314-67-4
TTD Drug ID
DMSYOHD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-APB DM9AKVR Discovery agent N.A. Investigative [3]
sphinganine DM9ZBLE Discovery agent N.A. Investigative [2]
epipregnanolone sulphate DMW271Q Discovery agent N.A. Investigative [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Long transient receptor potential channel 3 (TRPM3) TTO3TD8 TRPM3_HUMAN Activator [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2454).
2 Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]. Mol Pharmacol. 2005 Mar;67(3):798-805.
3 Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Br J Pharmacol. 2005 Jun;145(4):405-14.
4 Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br J Pharmacol. 2010 Sep;161(2):430-41.