Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSZML2)

Drug Name
6-chloro-5-(2-thienyl)pyrimidine-2,4(1H,3H)-dione Drug Info
Synonyms 6-chloro-5-(2-thienyl)pyrimidine-2,4(1H,3H)-dione; 1000680-81-8; CHEMBL397364; BDBM20069; 5-Substituted-6-chlorouracil, 10e
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
23648522
TTD Drug ID
DMSZML2

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
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Drug(s) Targeting Thymidine phosphorylase (TYMP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Uridine DMQTREB Depression 6A70-6A7Z Approved [2]
5-bromo-6-hydrazinouracil hydrochloride DMZJE6M Discovery agent N.A. Investigative [3]
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil DMEV0GO Discovery agent N.A. Investigative [4]
6-chloro-5-phenylpyrimidine-2,4(1H,3H)-dione DM90JMN Discovery agent N.A. Investigative [1]
6-chloro-5-heptylpyrimidine-2,4(1H,3H)-dione DMASFR6 Discovery agent N.A. Investigative [1]
1-(cyclohexyl)methyl-5'-O-tritylinosine DMS3XUC Discovery agent N.A. Investigative [5]
1-(cyclopropyl)methyl-5'-O-tritylinosine DMDU3X7 Discovery agent N.A. Investigative [5]
1-propyl-5'-O-tritylinosine DM5P01L Discovery agent N.A. Investigative [5]
1-allyl-5'-O-tritylinosine DM2J5WH Discovery agent N.A. Investigative [5]
5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione DMCKODQ Discovery agent N.A. Investigative [1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thymidine phosphorylase (TYMP) TTO0IB8 TYPH_HUMAN Inhibitor [1]

References

1 Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23.
2 Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues. Hum Cell. 2007 Nov;20(4):107-10.
3 Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7.
4 The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1648-51.
5 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70.