Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT3MBD)

Drug Name

CAY10583 Drug Info

Synonyms

compound A [PMID:15866883]; CAY 10583; CAY-10583

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Leukotriene B4 receptor 2 (LTB4R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LTB4	DME26RS	Human immunodeficiency virus infection	1C62	Phase 2	[2]
Biomed 101	DMQ9KZW	Kidney cancer	2C90.0	Phase 1	[2]
ONO-4057	DMNEA78	Inflammatory bowel disease	DD72	Discontinued in Phase 2	[3]
CP-105696	DM1C4IN	Inflammatory bowel disease	DD72	Discontinued in Phase 1	[4]
LY-292728	DMU24HR	N. A.	N. A.	Terminated	[5]
LY-255283	DMFIR0S	Asthma	CA23	Terminated	[6]
LY-282210	DMBSFDE	Discovery agent	N.A.	Investigative	[5]
(3S,4R)-3-Benzyl-7-isopropyl-chroman-4-ol	DMET6IS	Discovery agent	N.A.	Investigative	[4]
12S-HETE	DMBEZ09	Discovery agent	N.A.	Investigative	[7]
ZK-158252	DMNMD0J	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem. 2005 Jul 1;280(26):24816-23.
2	Diaryl ether/carboxylic acid derivatives of LY255283: Receptor antagonists of leukotriene B4, Bioorg. Med. Chem. Lett. 3(10):1985-1990 (1993).
3	ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75.
4	3-Substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor, Bioorg. Med. Chem. Lett. 7(17):2307-2312 (1997).
5	Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3982-4.
6	o-phenylphenols: potent and orally active leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3978-81.
7	Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001 Apr 13;276(15):12454-9.