Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT5O8I)

Drug Name

Axokine Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Discontinued in Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Acetyl-CoA carboxylase 2 (ACACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metformin	DM89QE1	Colorectal carcinoma		Approved	[3]
PF-05175157	DMLQ3OK	Type-2 diabetes	5A11	Phase 2	[4]
CP-640186	DMO0PS9	Discovery agent	N.A.	Investigative	[5]
A-80040	DML20N9	Discovery agent	N.A.	Investigative	[6]
AC-8632	DM09BJ4	Parkinson disease	8A00.0	Investigative	[4]
QLT-091382	DMWOSFJ	Sebaceous gland disease	EM0Z	Investigative	[4]
2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid	DMWXI06	Discovery agent	N.A.	Investigative	[7]
Soraphen A	DM18IKZ	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetyl-CoA carboxylase 2 (ACACB)	TTY84UG	ACACB_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007390)
2	Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
3	AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. Biochem Pharmacol. 2009 Jun 1;77(11):1684-93.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1264).
5	(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8.
6	Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acet... J Med Chem. 2006 Jun 29;49(13):3770-3.
7	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
8	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.