Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT60AM)

Drug Name
5-(piperidin-1-ylsulfonyl)indoline-2,3-dione Drug Info
Synonyms
329905-79-5; 5-(piperidin-1-ylsulfonyl)indoline-2,3-dione; 5-(piperidin-1-ylsulfonyl)-1H-indole-2,3-dione; 5-(Piperidine-1-sulfonyl)-1H-indole-2,3-dione; 5-[1-(Piperidinyl)sulfonyl]isatin; Isatin Sulfonamide 21; AC1N3S5Q; CHEMBL61320; BDBM10310; DTXSID40399501; MolPort-000-149-258; ZX-BK002316; ZINC2944779; MIX-0755; STK894352; BBL021638; 2990AJ; AKOS005144288; MCULE-6394963078; 5-(Piperidinosulfonyl)indoline-2,3-dione; AJ-44313; ACM329905795; AX8291419; H8238; 5-(piperidinosulfonyl)-1H-indole-2,3-dione
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4117383
ChEBI ID
CHEBI:149998
CAS Number
CAS 329905-79-5
TTD Drug ID
DMT60AM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PAC1 DMYQUIP Anaplastic astrocytoma 2A00.0 Phase 1 [2]
M826 DM9NPE4 Discovery agent N.A. Investigative [3]
Isoquinoline-1,3,4(2H)-trione DMT4RI2 Discovery agent N.A. Investigative [4]
Glionitrin A DM98CSW Solid tumour/cancer 2A00-2F9Z Investigative [5]
Ac-DEVD-CHO DMW02H7 Discovery agent N.A. Investigative [6]
SJ-8002 DMEQBU2 Solid tumour/cancer 2A00-2F9Z Investigative [7]
AZ10417808 DMNO6PL Discovery agent N.A. Investigative [8]
2-phenethylisoquinoline-1,3,4-trione DMPWG21 Discovery agent N.A. Investigative [4]
2-benzylisoquinoline-1,3,4-trione DME7SAV Discovery agent N.A. Investigative [4]
2-(4-methoxy-benzyl)isoquinoline-1,3,4-trione DMHAE31 Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Caspase-3 (CASP3) TTPF2QI CASP3_HUMAN Inhibitor [1]

References

1 Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach. Bioorg Med Chem. 2009 Aug 15;17(16):6040-7.
2 Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2(10):543-50.
3 Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80.
4 Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23.
5 Glionitrin A, a new diketopiperazine disulfide, activates ATM-ATR-Chk1/2 via 53BP1 phosphorylation in DU145 cells and shows antitumor effect in xenograft model. Biol Pharm Bull. 2014;37(3):378-86.
6 Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. Eur J Med Chem. 2010 Sep;45(9):3858-63.
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1619).
8 Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis. J Pharmacol Exp Ther. 2003 Jan;304(1):433-40.