Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT6KI7)

Drug Name
Alpha-Phosphoribosylpyrophosphoric Acid Drug Info
Synonyms
PRPP; PHOSPHORIBOSYL PYROPHOSPHATE; 5-Phospho-alpha-D-ribose 1-diphosphate; 5-Phosphoribosyl diphosphate; PRib-PP; 7540-64-9; phosphoribosylpyrophosphate; 5-Phosphoribosyl 1-pyrophosphate; Ribofuranose, 5-phosphate 1-pyrophosphate; PQGCEDQWHSBAJP-TXICZTDVSA-N; 5-Phosphorylribose 1-pyrophosphate; alpha-D-Ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate); 13270-65-0; 5-PHOSPHORYLRIBOSE-1-PYROPHOSPHATE; 5-phosphoribosyl-1-pyrophosphate
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
7339
ChEBI ID
CHEBI:17111
CAS Number
CAS 7540-64-9
TTD Drug ID
DMT6KI7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Orotidine 5'-monophosphate decarboxylase (UMPS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
6-Hydroxyuridine-5'-Phosphate DMDMNQV Discovery agent N.A. Investigative [2]
Pyrazofurin DMVJLSM Discovery agent N.A. Investigative [3]
5-fluoro-6-azido-UMP DMZLJRS Discovery agent N.A. Investigative [4]
5-fluoro-6-amino-UMP DM6QHIA Discovery agent N.A. Investigative [4]
5-fluoro-6-iodo-UMP DM3LMIS Discovery agent N.A. Investigative [4]
5-Fluoro-6-ethyluridine-5'-O-monophosphate DMTAZ71 Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Targeting Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
US9200020, Table 3, Compound 1B DMEARS2 N. A. N. A. Patented [5]
US9200020, Table 3, Compound 2B DMXFB5Z N. A. N. A. Patented [5]
US9200020, Table 3 compound 8 DMCLHX5 N. A. N. A. Patented [5]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [2]
Formic Acid DMNFZC6 Discovery agent N.A. Investigative [2]
Pyrophosphate 2- DMZQ75M Discovery agent N.A. Investigative [1]
Guanosine-5'-Monophosphate DM3SLZK Discovery agent N.A. Investigative [2]
Inosinic Acid DMLR86H Discovery agent N.A. Investigative [2]
Carboxylic PRPP DMCTUR1 Discovery agent N.A. Investigative [2]
5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine DMX0EAK Discovery agent N.A. Investigative [2]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Orotidine 5'-monophosphate decarboxylase (UMPS) TTAFJUD UMPS_HUMAN Inhibitor [1]
Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) TTBL49X HGXR_PLAFG Inhibitor [1]

References

1 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75.
4 Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58.
5 6-oxopurine phosphoribosyltransferase inhibitors. US9200020.