Details of the Drug-Related molecule(s) Interaction Atlas

SQ-34919 Drug Info

SQ-34919; CHEMBL286760; SCHEMBL9632769; SCHEMBL9632781; GTPL3101; BDBM50031839; (6,10-Dimethyl-5,9-undecadienylidene)bisphosphonic acid; ((E)-6,10-Dimethyl-1-phosphono-undeca-5,9-dienyl)-phosphonic acid; [(5E)-6,10-dimethyl-1-phosphonoundeca-5,9-dien-1-yl]phosphonic acid

Cross-matching ID

PubChem CID

10382597

TTD Drug ID

DMT7O9V

General Information of Drug (ID: DMT7O9V)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Squalene synthetase (FDFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lapaquistat acetate	DMJY9CW	Hyperlipidaemia	5C80	Discontinued in Phase 3	[2]
SQ-32709	DMSQRXW	Arteriosclerosis	BD40	Discontinued in Phase 2	[3]
BMS-187745	DMP8SIV	Hyperlipidaemia	5C80	Discontinued in Phase 2	[4]
Squalestatin 1	DM4JZPT	Arteriosclerosis	BD40	Terminated	[5]
A-87049	DMUID46	N. A.	N. A.	Terminated	[6]
RPR-101821	DM21Y75	Arteriosclerosis	BD40	Terminated	[7]
L-735021	DM8BVJQ	Discovery agent	N.A.	Investigative	[8]
PMID19191557C32	DMH8QRI	Discovery agent	N.A.	Investigative	[4]
PMID9871507C14	DMY28QM	Discovery agent	N.A.	Investigative	[9]
PMID19456099C13	DMBU9E4	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Squalene synthetase (FDFT1)	TTFQEO5	FDFT_HUMAN	Inhibitor	[1]

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References

1	Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine, Bioorg. Med. Chem. Lett. 6(12):1291-1296 (1996).
2	Lapaquistat acetate, a squalene synthase inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous le... Br J Pharmacol. 2008 Jul;154(5):949-57.
3	Clinical pharmacokinetics and pharmacodynamics of a new squalene synthase inhibitor, BMS-188494, in healthy volunteers. J Clin Pharmacol. 1998 Dec;38(12):1116-21.
4	Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26;52(4):976-88.
5	Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo. J Biol Chem. 1992 Jun 15;267(17):11705-8.
6	(1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent ... J Med Chem. 1997 Jul 4;40(14):2123-5.
7	RPR 101821, a new potent cholesterol-lowering agent: inhibition of squalene synthase and 7-dehydrocholesterol reductase. Naunyn Schmiedebergs Arch Pharmacol. 1996 Jan;353(2):233-40.
8	Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives. J Med Chem. 1994 Nov 11;37(23):4031-51.
9	Cyclopentanedi- and tricarboxylic acids as squalene synthase inhibitors: syntheses and evaluation. Bioorg Med Chem Lett. 1998 Apr 21;8(8):891-6.
10	Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. J Med Chem. 2009 Jul 9;52(13):3869-80.