Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTCOY9)

Drug Name

C3 Drug Info

Synonyms

4-[2-[2-[3-acetamido-2-[[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoylamino]propanoylamino]-5-[[6-amino-1-[[1-[(1-hydroxy-1-oxopropan-2-yl)amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-oxopentanoic acid; AC1L18UY

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 268
TTD Drug ID: DMTCOY9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Melanin-concentrating hormone receptor 1 (MCHR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMS-830216	DMCW71N	Obesity	5B81	Phase 1	[3]
AZD1979	DMQ1OX4	Obesity	5B81	Phase 1	[4]
PMID25522065-Compound-27	DMXN4KB	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-29	DMBNAK9	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-34	DMZDIRQ	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-39	DM5YMQH	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-40	DMCIQ01	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-11	DM410Z6	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-50	DMBWA0V	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-12	DMVKO9C	N. A.	N. A.	Patented	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melanin-concentrating hormone receptor 1 (MCHR1)	TTX4RTB	MCHR1_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1291).
2	SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study. J Pharmacol Exp Ther. 2001 Oct;299(1):137-46.
3	2011 Pipeline of Bristol-Myers Squibb.
4	Phase I clinical trial of AZD1979 for treating obesity. AstraZeneca plc
5	Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207.