Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTDG7L)

Drug Name
Z-VAD-fmk Drug Info
Synonyms
187389-52-2; Z-VAD(OMe)-FMK; z-vad-FMK; Z-VAD (OMe)-FMK; Z-Val-Ala-Asp(OMe)-FMK; ZVAD-FMK; 5-Bromo-2 -deoxyuridine; Z-Val-Ala-Asp(OMe)-fluoromethyl ketone; Z-Val-Ala-Asp(OMe)-CH2F; C22H30FN3O7; Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone; Caspase-1 Inhibitor Z-Val-Ala-DL-Asp-fluoromethylketone; z-Val-Ala-Asp(OMe)-fluoromethylketone; Z-Val-Ala-Asp(OCH3)-fluoromethylketone; L-alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-; methyl 5-fluoro-3-[2-[[3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoylamino]-4-oxopentanoate; benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethyl ketone; N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone; N-benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone; MFCD02684037; Bio2_000471; zVAD; pan-caspase inhibitor; Z-VAD-(OMe)-FMK; Probes1_000501; CBiol_001923; BSPBio_001262; KBioGR_000602; KBioSS_000602; CHEMBL1213366; SCHEMBL15012737; Z-Val-Ala-Asp(OCH3)-CH2F; KBio2_000602; KBio2_003170; KBio2_005738; KBio3_001063; KBio3_001064; AOB5976; DTXSID40420586; CHEBI:137045; Bio1_000209; Bio1_000698; Bio1_001187; Bio2_000951; HMS1362P03; HMS1792P03; HMS1990P03; HMS3403P03; EX-A2192; ZINC3875327; 2822AH; Z-L-Val-L-Ala-L-Asp(OMe)-CH2F; AKOS024456966; z-Val-Ala-Asp(OMe) fluoromethylketone; CCG-207882; CS-3153; IDI1_002226; z-Val-Ala-Asp(OMe)-fluoromethyl-ketone; Cbz-Val-Ala-Asp(OMe)-fluoromethylketone; NCGC00163487-01; NCGC00163487-02; AS-74918; Cbz-Val-Ala-Asp(OMe)-fluoromethyl ketone; HY-16658; Z-Val-Ala-Asp(OCH3)-fluoromethyl ketone; z-Val-Ala-Asp(O-methyl)-fluoromethylketone; S7023; SW219162-1; Caspase Inhibitor I - CAS 187389-52-2; A12373; Z-VAD(OMe)-FMK; Z-Val-Ala-Asp(OMe)-FMK; J-012061; benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethyl ketone; benzyloxycarbonyl-Val-Ala-Asp(OMe)fluoromethyl ketone; N-benzyloxycarbonyl-Val-Ala-Asp(OMe)fluoromethylketone; benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone; N-benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethyl ketone; N-benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethylketone; N-benzyloxycarbonyl-Val-Ala-Asp(OMe)fluoromethyl ketone; benzyloxycarbonyl-Val-Ala-Asp(O-methyl)-fluoromethylketone; N-benzyloxycarbonyl-Val-Ala-Asp(O-methyl) fluoromethyl ketone; N-benzyloxycarbonyl-Val-Ala-Asp(O-methyl)-fluoromethyl ketone; N-benzyloxycarbonyl-Val-Ala-Asp(O-methyl)-fluoromethylketone; L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]- (9CI); METHYL (3S)-3-[(2S)-2-[(2S)-2-{[(BENZYLOXY)CARBONYL]AMINO}-3-METHYLBUTANAMIDO]PROPANAMIDO]-5-FLUORO-4-OXOPENTANOATE; N-[(benzyloxy)carbonyl]-L-valyl-N-[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]-L-alaninamide; Methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoate
Indication
Disease Entry ICD 11 Status REF
Pulmonary fibrosis CB03.4 Preclinical [1]
Cross-matching ID
PubChem CID
5497174
ChEBI ID
CHEBI:137045
CAS Number
CAS 187389-52-2
TTD Drug ID
DMTDG7L

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Preclinical Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Caspase (CASP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NCX-1000 DM2YIZH Cardiovascular disease BA00-BE2Z Phase 2 [3]
VX-166 DMZKY56 Hepatic fibrosis DB93.0 Preclinical [4]
ALS-769 DMGBT9Z Solid tumour/cancer 2A00-2F9Z Terminated [5]
Isoquinoline-1,3,4(2H)-trione DMT4RI2 Discovery agent N.A. Investigative [6]
Ac-DEVD-CHO DMW02H7 Discovery agent N.A. Investigative [7]
2-aminophenoxazine-3-one DMBVGAO T-cell leukaemia 2A90 Investigative [8]
IDN-1965 DMRQSN2 Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Caspase (CASP) TTZY5KP NOUNIPROTAC Inhibitor [2]

References

1 Drugs and Targets in Fibrosis. Front Pharmacol. 2017 Nov 23;8:855.
2 Clinical pipeline report, company report or official report of InvivoGen.
3 Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice. Br J Pharmacol. 2004 Sep;143(1):33-42.
4 VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis. Crit Care. 2009;13(5):R146.
5 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025089)
6 Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23.
7 Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. Eur J Med Chem. 2010 Sep;45(9):3858-63.
8 Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197.
9 Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic ... Circulation. 2003 Dec 16;108(24):3036-41.