Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTFU8Q)

Drug Name
OMP-131R10 Drug Info
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMTFU8Q

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting R-spondin-3 (RSPO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rosmantuzumab DM9O3RY Colorectal cancer 2B91.Z Phase 1 [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
R-spondin-3 (RSPO3) TT7HJTF RSPO3_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT02482441) A Phase 1a/b Dose Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of OMP-131R10. U.S. National Institutes of Health.
2 Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. PLoS One. 2020 Mar 11;15(3):e0229445.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)