Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTFUM4)

Drug Name

IMMU-114 Drug Info

Synonyms

HLA-DR mAb (cancer), Immunomedics

Indication

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting MHC class II antigen DR (HLA-DR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apolizumab	DMKVP7E	Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]
AEA-35p	DMQRKXP	Influenza virus infection	1E30-1E32	Phase 1	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MHC class II antigen DR (HLA-DR)	TTYA75N	DRA_HUMAN; 2B1F_HUMAN; DRB3_HUMAN; DRB4_HUMAN; DRB5_HUMAN	Not Available	[3]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800039238)
3	The humanized anti-HLA-DR moAb, IMMU-114, depletes APCs and reduces alloreactive T cells: implications for preventing GVHD. Bone Marrow Transplant. 2012 Jul;47(7):967-80.
4	A humanized HLA-DR antibody (hu1D10, apolizumab) in combination with granulocyte colony-stimulating factor (filgrastim) for the treatment of non-Hodgkin's lymphoma: a pilot study.
5	WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting.