Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTHLB8)

Drug Name

FA-613 Drug Info

Synonyms

6-bromo-2-(4-ethoxyphenyl)-4-quinolinecarboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[1]
Severe acute respiratory syndrome (SARS)	1D65	Preclinical	[1]

Therapeutic Class

Antiviral Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting HUMAN dihydroorotate dehydrogenase (DHODH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[2]
IMU-838	DM5UJ9P	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2/3 Trial	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HUMAN dihydroorotate dehydrogenase (DHODH)	TT3UY29	PYRD_HUMAN	Inhibitor	[1]

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References

1	Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response. J Gen Virol. 2017 May;98(5):946-954.
2	On dihydroorotate dehydrogenases and their inhibitors and uses. J Med Chem. 2013 Apr 25;56(8):3148-67. doi: 10.1021/jm301848w.
3	IMU-838 Targeting DHODH