General Information of Drug (ID: DMTI10C)

Drug Name
CEP-427 Drug Info
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Terminated [1]
Cross-matching ID
TTD Drug ID
DMTI10C

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cenegermin DM8Y2RU Neurotrophic keratitis 9A74 Approved [3]
Fulranumab DMK38MV Arthralgia ME82 Phase 3 [2]
SPI-205 DMHC2AW Parkinson disease 8A00.0 Phase 2 [4]
LM11A-31 DM095HQ Alzheimer disease 8A20 Phase 1/2 [5]
LM11A-31 DM095HQ Alzheimer disease 8A20 Phase 1/2 [6]
Org-2766 DMVRA8N Cognitive impairment 6D71 Discontinued in Phase 3 [7]
BU-4514N DMJDMTK Alzheimer disease 8A20 Terminated [8]
ReN-1820 DMWIAUK Cystitis GC00 Terminated [9]
TDI-0059 DMSI9QM Motor neurone disease 8B60 Investigative [2]
Nerve growth factor conjugated RAP peptide DM3AW8X Neurodegenerative disorder 8A20-8A23 Investigative [2]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Low-affinity nerve growth factor receptor (NGFR) TTEDJN4 TNR16_HUMAN Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006555)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888).
3 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
4 AIT-082 NeoTherapeutics Inc. IDrugs. 1998 Oct;1(6):694-9.
5 Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.Neurobiol Aging.2013 Aug;34(8):2052-63.
6 Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. 2019 Aug;62(8):1488-1500.
7 Effects of the ACTH4-9 analog Org2766 on brain plasticity: modulation of excitatory neurotransmission. Psychoneuroendocrinology. 1992 Aug;17(4):315-25.
8 A new neuritogenetic compound BU-4514N produced by Microtetraspora sp. J Antibiot (Tokyo). 1993 Jun;46(6):875-83.
9 Phosphorylation of Extracellular Signal-Regulated Kinases (pERK1/2) in Bladder Afferent Pathways with Cyclophosphamide (CYP)-Induced Cystitis. Neuroscience. 2009 November 10; 163(4): 1353-1362.