Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTJDXY)

Drug Name

ESI-09 Drug Info

Synonyms

ESI 09; ESI09

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Rap guanine nucleotide exchange factor 4 (EPAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HJC 0350	DMNI5FW	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Rap guanine nucleotide exchange factor 4 (EPAC2)	TTOS63B	RPGF4_HUMAN	Inhibitor	[2]

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References

1	Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8.
2	A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol Pharmacol. 2013 Jan;83(1):122-8.
3	Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J Med Chem. 2013 Feb 14;56(3):952-62.