Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTNOXQ)

Drug Name

OT-551 Drug Info

Synonyms

Tempol-H prodrug, Othera

Indication

Disease Entry	ICD 11	Status	REF
Ocular inflammation	9C61.24	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Nuclear factor erythroid 2-related factor 2 (Nrf2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Omaveloxolone	DMLMNFX	Friedreich's ataxia	8A03.10	Approved	[3]
CXA10	DMM7Z6K	Focal segmental glomerulosclerosis	MF8Y	Phase 2	[4]
SFX-01	DMAQW9M	Breast cancer	2C60-2C65	Phase 2	[5]
ABT-RTA-408	DM9Y1XB	Non-small-cell lung cancer	2C25.Y	Phase 2	[6]
OT551	DMHKIOF	Age-related macular degeneration	9B75.0	Phase 2	[7]
HPP971	DMZXG7Q	Non-alcoholic steatohepatitis	DB92.1	Phase 1	[8]
PMID28454500-Compound-57	DMTK9M6	N. A.	N. A.	Patented	[9]
PMID28454500-Compound-8	DM6BQFA	N. A.	N. A.	Patented	[9]
Pyrazino[2,1-a]isoquinolin derivative 4	DMKTNBC	N. A.	N. A.	Patented	[9]
PMID28454500-Compound-36	DM5RZWG	N. A.	N. A.	Patented	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nuclear factor erythroid 2-related factor 2 (Nrf2)	TTA6ZN2	NF2L2_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT00306488) OT-551 Antioxidant Eye Drops to Treat Geographic Atrophy in Age-Related Macular Degeneration. U.S. National Institutes of Health.
2	New hope for dry AMD. Nat Rev Drug Discov. 2013 Jul;12(7):501-2.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases. Biophys Rev. 2017 Feb;9(1):41-56.
5	Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nat Rev Drug Discov. 2019 Apr;18(4):295-317.
6	National Cancer Institute Drug Dictionary (drug id 756624).
7	Nitroxide pharmaceutical development for age-related degeneration and disease. Front Genet. 2015 Nov 6;6:325.
8	Clinical pipeline report, company report or official report of vTv Therapeutics.
9	Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785.