Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTOEJX)

Drug Name
Acid-activated omeprazole Drug Info
Synonyms
Hydroxyfasudil; HYDROXYFASUDIL; 105628-72-6; Hydroxy-Fasudil; 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine; HA 1100; HA-1100; 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE; CHEMBL1233300; Hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-1H-1,4-diazepine; 5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one; HYDROXYFASUDIL;5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one; 1H-1,4-Diazepine, hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-; HFS; 2etk; 2erz; AC1MI8J4; SCHEMBL123699
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
3064778
CAS Number
CAS 105628-72-6
TTD Drug ID
DMTOEJX
VARIDT Drug ID
DR00804

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Chloride channel protein 2 (CLC-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lubiprostone DMJTEMW Chronic idiopathic constipation DC32 Approved [3]
RK-023 DM2VO97 Alopecia ED70 Phase 2 [4]
NPPB DMFIWAN Discovery agent N.A. Investigative [5]
diphenylamine-2-carboxylic acid DMBV19T Discovery agent N.A. Investigative [5]
Drug(s) Targeting Rho-associated protein kinase 1 (ROCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Netarsudil DM0LPI9 Open-angle glaucoma 9C61 Approved [6]
SAR-407899 DMF95KD Diabetic nephropathy GB61.Z Phase 2 [7]
H-1152 DM8XH3S Pulmonary arterial hypertension BB01.0 Phase 2 [8]
INS-117548 DMA46DO Glaucoma/ocular hypertension 9C61 Phase 1 [4]
GSK269962A DM5I2HL Inflammation 1A00-CA43.1 Clinical trial [9]
PMID28048944-Compound-19 DMPT3V9 N. A. N. A. Patented [10]
PMID28048944-Compound-3 DM1BN74 N. A. N. A. Patented [10]
PMID28048944-Compound-7 DMXZ368 N. A. N. A. Patented [10]
PMID28048944-Compound-4 DMJAUWG N. A. N. A. Patented [10]
PMID28048944-Compound-5 DMAB987 N. A. N. A. Patented [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Chloride channel protein 2 (CLC-2) TT30NW6 CLCN2_HUMAN Activator [1]
Rho-associated protein kinase 1 (ROCK1) TTZN7RP ROCK1_HUMAN Inhibitor [2]

References

1 ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole. Am J Physiol Cell Physiol. 2001 Jul;281(1):C46-54.
2 Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice. Circ Res. 2004 Jan 9;94(1):46-52.
3 Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans. Am J Physiol Lung Cell Mol Physiol. 2009 May;296(5):L811-24.
4 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 699).
6 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
7 The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. J Hypertens. 2012 May;30(5):980-9.
8 Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19.
9 Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.
10 Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515.