Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTOI7S)

Drug Name
ARRY-520 Drug Info
Synonyms
Filanesib; ARRY-520; 885060-09-3; UNII-8A49OSO368; Arry520; CHEMBL2347655; ARRY 520 trifluoroacetate; 8A49OSO368; ARRY 520; (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide; Filanesib [INN]; Filanesib [USAN:INN]; C20H22F2N4O2S; ARRY-520; Filanesib; 1385020-40-5; Filanesib(ARRY-520); SCHEMBL368043; DTXSID50237086; EX-A678; BCP07442; ZINC43204022; 3452AH; BDBM50431893; AKOS030526964; SB19209; RL05514; CS-0867; NCGC00381751-02; NCGC00381751-04
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
44224257
CAS Number
CAS 885060-09-3
TTD Drug ID
DMTOI7S

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Kinesin-like protein KIF11 (KIF11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AZD-4877 DMFVL5J Acute myeloid leukaemia 2A60 Phase 2 [4]
Ispinesib DMP2BWX Head and neck cancer 2D42 Phase 2 [5]
SB-743921 DM6XJ9S Solid tumour/cancer 2A00-2F9Z Phase 2 [6]
LY2523355 DMCV602 Acute myeloid leukaemia 2A60 Phase 2 [4]
ARQ 621 DMCRLQZ Haematological malignancy 2B33.Y Phase 1 [4]
4SC-205 DMG75P3 Lymphoma 2A80-2A86 Phase 1 [7]
MK-0731 DM2TAUR Solid tumour/cancer 2A00-2F9Z Phase 1 [4]
Monastrol DMLSEJN Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kinesin-like protein KIF11 (KIF11) TTTRP0H KIF11_HUMAN Inhibitor [3]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT01989325) A Study of Filanesib (ARRY-520) and Carfilzomib in Patients With Advanced Multiple Myeloma. U.S. National Institutes of Health.
3 Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. Leukemia. 2009 Oct;23(10):1755-62.
4 Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39.
5 Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. Pediatr Blood Cancer. 2009 Dec 15;53(7):1255-63.
6 Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Jan-Feb;31(1):47-57.
7 2011 Pipeline of 4SC AG.
8 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.