Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTW9GM)

Drug Name
GW-2580 Drug Info
Synonyms GW2580; cFMS receptor tyrosine kinase inhibitor; GW632580X
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11617559
CAS Number
CAS 870483-87-7
TTD Drug ID
DMTW9GM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting CSF1R messenger RNA (CSF1R mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
JNJ-28312141 DMCMH7O Discovery agent N.A. Investigative [2]
Ki-20227 DM9M3VC Discovery agent N.A. Investigative [2]
GTP-14564 DMW23Y9 Discovery agent N.A. Investigative [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CSF1R messenger RNA (CSF1R mRNA) TTVW6QL CSF1R_HUMAN Inhibitor [1]

References

1 Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83.
2 Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51.
3 Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosin... J Biol Chem. 2003 Aug 29;278(35):32892-8.