General Information of Drug (ID: DMTZYQ3)

Drug Name
LP99 Drug Info
Synonyms compound 60 [PMID: 25864491]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
91827372
TTD Drug ID
DMTZYQ3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
I-BRD9 DM9C8FP Discovery agent N.A. Investigative [2]
BI 7273 DMI3ANC Acute myeloid leukaemia 2A60 Investigative [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bromodomain-containing protein 7 (BRD7) TT07ZS1 BRD7_HUMAN Inhibitor [1]
Bromodomain-containing protein 9 (BRD9) TTR7L5Y BRD9_HUMAN Inhibitor [1]

References

1 LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54(21):6217-21.
2 Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. J Med Chem. 2016 Feb 25;59(4):1425-39.
3 Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J Med Chem. 2016 May 26;59(10):4462-75.