General Information of Drug (ID: DMU13BY)

Drug Name
BzT-7 Drug Info
Synonyms
CHEMBL1958337; 8-Chloro-1,4-Dimethyl-6-Phenyl-4h-[1,2,4]triazolo[4,3-A][1,3,4]benzotriazepine; BzT-7; 3u5l; GTPL7515; SCHEMBL11468349; UYIVCPRWMLOCSB-UHFFFAOYSA-N; BDBM50365263; 8-chloro-1,4-dimethyl-6-phenyl-[1,2,4]triazolo[4,3-a][1,3,4]benzotriazepine; 8-chloro-1,4-dimethyl-6-phenyl-4H-s-triazolo(4,3-a)(1,3,4)benzotriazepine; 8-chloro-1,4-dimethyl-6-phenyl-4H-s-triazolo(4,3-a)(1,3,4 )benzotriazepine; 8-chloro-1,4-dimethyl-6-phenyl-4H-s-triazolo(4,3-a) (1,3,4)benzotriazepine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
20350618
TTD Drug ID
DMU13BY

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CPI-0610 DMPXOYJ Myelofibrosis 2A20.2 Phase 3 [2]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [2]
PLX2853 DMX168L Acute myeloid leukaemia 2A60 Phase 1/2 [3]
RVX-208 DM1LO8K Alzheimer disease 8A20 Phase 1/2 [2]
INCB57643 DMBGU7V Advanced malignancy 2A00-2F9Z Phase 1/2 [3]
ABBV-744 DMTEA9C Acute myeloid leukaemia 2A60 Phase 1 [3]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [4]
GSK525762 DMPAWBN Haematological malignancy 2B33.Y Phase 1 [2]
TEN010 DM4UOY5 Advanced solid tumour 2A00-2F9Z Phase 1 [2]
AZD5153 DMW4GM2 Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bromodomain-containing protein 4 (BRD4) TTRA6BO BRD4_HUMAN Inhibitor [1]

References

1 Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorg Med Chem. 2012 Mar 15;20(6):1878-86.
2 Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.