Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU21PD)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Leucyl-cysteinyl aminopeptidase (LNPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US10059720, Example 80	DMBD95S	N. A.	N. A.	Patented	[2]
US10059720, Example 82	DMJ6GU9	N. A.	N. A.	Patented	[2]
US10059720, Example 84	DMKLVE4	N. A.	N. A.	Patented	[2]
US10023583, Example 5	DMZR10T	N. A.	N. A.	Patented	[1]
US10023583, Example 24	DM5LK6O	N. A.	N. A.	Patented	[1]
US10023583, Example 8	DM40KU8	N. A.	N. A.	Patented	[1]
PMID23916253C17	DM35FH8	Discovery agent	N.A.	Investigative	[3]
inhibitor 19	DMWIHRX	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leucyl-cysteinyl aminopeptidase (LNPEP)	TTY2KP7	LCAP_HUMAN	Inhibitor	[1]

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References

1	Bicyclic pyridine compound. US10023583.
2	Pyridine derivative. US10059720.
3	Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4832-6.
4	Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis. J Med Chem. 2011 Jun 9;54(11):3779-92.