Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU2EKN)

• Drug Name: Ro 40-6055 Drug Info
• Synonyms: AM580; CD-336; Ro406055

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 2126
  ChEBI ID: CHEBI:64210
  CAS Number: CAS 102121-60-8
  TTD Drug ID: DMU2EKN

Molecule-Related Drug Atlas

Drug(s) Targeting Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[3]
IRX-5183	DMCED9U	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
SY-1425	DMH8UF0	Acute myeloid leukaemia	2A60	Phase 1	[5]
PMID27336223-Compound-4	DMJFSOM	N. A.	N. A.	Patented	[6]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[6]
LG100268	DM41RK2	Acquired immune deficiency syndrome	1C62.3	Discontinued in Phase 1	[7]
CD666	DMC8X9Y	Discovery agent	N.A.	Investigative	[8]
AGN193109	DMC0YOE	Discovery agent	N.A.	Investigative	[9]
AGN193836	DMEB93D	Discovery agent	N.A.	Investigative	[10]
BMS614	DMZWNO9	Discovery agent	N.A.	Investigative	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor alpha (RARA)	TTW38KT	RARA_HUMAN	Agonist	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2647).
• [2] Selective high affinity retinoic acid receptor alpha or beta-gamma ligands. Mol Pharmacol. 1991 Oct;40(4):556-62.
• [3] Tamibarotene: a candidate retinoid drug for Alzheimer's disease. Biol Pharm Bull. 2012;35(8):1206-12.
• [4] Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat. J Mol Med (Berl). 2004 Feb;82(2):116-25.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71.
• [7] Placental steroidogenesis in rats is independent of signaling pathways induced by retinoic acids. Gen Comp Endocrinol. 2009 Sep 15;163(3):285-91.
• [8] Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83.
• [9] Therapeutic applications for ligands of retinoid receptors. Curr Pharm Des. 2000 Jan;6(1):25-58.
• [10] Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8.
• [11] Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature. 2002 Jan 10;415(6868):187-92.