Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU2ZFK)

Drug Name

CT-2584 Drug Info

Synonyms

Apra (Cell Therapeutics, US, US); 1-[11-(Dodecylamino)-10-hydroxyundecyl]-3,7-dimethylxanthine

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Cholinephosphate cytidylyltransferase (PCYT1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sphingosine	DMO1FTI	N. A.	N. A.	Phase 1	[2]
Cholesterol	DMR3J6S	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholinephosphate cytidylyltransferase (PCYT1B)	TTUAIKM	PCY1B_HUMAN	Modulator	[1]

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References

1	Pharmacological inhibition of phosphatidylcholine biosynthesis is associated with induction of phosphatidylinositol accumulation and cytolysis of neoplastic cell lines. Cancer Res. 2000 Sep 15;60(18):5204-13.
2	Sphingosine inhibits the activity of rat liver CTP:phosphocholine cytidylyltransferase. J Biol Chem. 1990 Jul 15;265(20):11746-50.
3	Regulation of CTP: phosphocholine cytidylyltransferase activity by the physical properties of lipid membranes: an important role for stored curvature strain energy. Biochemistry. 2001 Sep 4;40(35):10522-31.