Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU42CR)

Drug Name

example 92 (WO2012095521) Drug Info

Synonyms

US8846658, 92; SCHEMBL363629; GTPL7856; CHEMBL3653509; BDBM18751; example 92 [WO2012095521]; US8846658, 93

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Beta-site APP-cleaving enzyme 2 (BACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
example 98 (WO2011020806)	DM2N653	Focal segmental glomerulosclerosis	MF8Y	Clinical trial	[1]
PMID21907142CJ	DMST0IN	Discovery agent	N.A.	Investigative	[3]
example 2 (WO2013004676)	DMU25HZ	Discovery agent	N.A.	Investigative	[4]
example 20 (WO2010128058)	DMF9W41	Discovery agent	N.A.	Investigative	[2]
example 41 (WO2012028563)	DM2N9Y8	Discovery agent	N.A.	Investigative	[2]
2ewy	DMNOAJG	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Beta-site APP-cleaving enzyme 2 (BACE2)	TT69DB8	BACE2_HUMAN	Inhibitor	[2]

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References

1	BACE2 as a new diabetes target: a patent review (2010 - 2012). Expert Opin Ther Pat. 2013 May;23(5):649-63.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2331).
3	Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab. 2011 Sep 7;14(3):365-77.
4	Cyclopropyl-Fused 1,3-Thiazepines as BACE1 and BACE2 Inhibitors. ACS Med Chem Lett. 2013 Mar 15;4(4):379-80.
5	Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor. J Mol Biol. 2006 Jan 13;355(2):249-61.