Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU6K37)

Drug Name

ABBV-2737 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Cystic fibrosis	CA25	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting cAMP-dependent chloride channel (CFTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivacaftor	DMZC1HS	Cystic fibrosis	CA25	Approved	[2]
Crofelemer	DM4AMQZ	HIV-associated diarrhoea	1A2Z	Approved	[3]
Tezacaftor and ivacaftor	DMY62FC	Acute lung injury	NB32.3	Approved	[4]
VX-661	DMJBXO3	Cystic fibrosis	CA25	Phase 3	[5]
ABBV-2222	DM4ZLTY	Cystic fibrosis	CA25	Phase 2	[1]
GLPG-1837	DMOCRYB	Cystic fibrosis	CA25	Phase 2	[1]
iOWH032	DM5TMYC	Diarrhea	ME05.1	Phase 2	[6]
Lumacaftor	DMCLWDJ	Cystic fibrosis	CA25	Phase 2	[7]
QBW251	DMQ5APT	Chronic obstructive pulmonary disease	CA22	Phase 2	[8]
ABBV-3067	DMB01L5	Cystic fibrosis	CA25	Phase 1	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
cAMP-dependent chloride channel (CFTR)	TTRLZHP	CFTR_HUMAN	Modulator	[1]

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References

1	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
4	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
5	CFTR Modulators for the Treatment of Cystic Fibrosis. P T. 2014 Jul;39(7):500-11.
6	Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25.
7	A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial. Lancet Respir Med. 2014 Jul;2(7):527-38.
8	Safety and efficacy of the cystic fibrosis transmembrane conductance regulator potentiator icenticaftor (QBW251). J Cyst Fibros. 2021 Mar;20(2):250-256.