Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUBEX4)

Drug Name

CAR-T cells targeting MAGE-A4 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Lung cancer	2C25.0	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Melanoma-associated antigen 4 (MAGEA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ADP-A2M4	DMRYH3M	Synovial sarcoma	2B5A	Phase 2	[2]
Afamitresgene autoleucel	DM1GR4M	Soft tissue sarcoma	2B57	Phase 2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melanoma-associated antigen 4 (MAGEA4)	TT9EQUY	MAGA4_HUMAN	CAR-T-Cell-Therapy	[1]

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References

1	ClinicalTrials.gov (NCT03356808) Antigen-specific T Cells Against Lung Cancer
2	Clinical pipeline report, company report or official report of Adaptimmune.
3	Autologous T cell therapy for MAGE-A4(+) solid cancers in HLA-A*02(+) patients: a phase 1 trial. Nat Med. 2023 Jan;29(1):104-114.