Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUBO3E)

• Drug Name: fenclonine Drug Info
• Synonyms: 4-chlorophenylalanine; para-chlorophenylalanine; PCPA

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 4652
  ChEBI ID: CHEBI:110187
  CAS Number: CAS 7424-00-2
  TTD Drug ID: DMUBO3E

Molecule-Related Drug Atlas

Drug(s) Targeting Phenylalanine hydroxylase (PAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sapropterin hydrochloride	DM90TJP	Hyperphenylalaninemia	5C50	Approved	[5]
Pegvaliase	DM6NZ2P	Phenylketonuria	5C50.0	Approved	[6]
Phenylalanine hydroxylase	DMRP3CV	Autoimmune diabetes	5A10	Phase 2	[7]
HepaStem	DM8QGPE	Liver failure	DB99.7	Phase 2	[3]
HMI-102	DM8B85Y	Phenylketonuria	5C50.0	Phase 1/2	[8]
BMN-307	DMY0SKM	Phenylketonuria	5C50.0	Phase 1/2	[9]
BMN-168	DM0VMZ4	Phenylketonuria	5C50.0	Investigative	[3]
ALTU-236	DMDLN9S	Genetic disease	8E02	Investigative	[3]
alpha-methylphenylalanine	DMAUH96	Discovery agent	N.A.	Investigative	[10]
BH4	DM4XMZW	Discovery agent	N.A.	Investigative	[11]

Drug(s) Targeting Tryptophan 5-hydroxylase 1 (TPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AGN-2979	DMLQRFO	Psychotic disorder	6A20-6A25	Phase 2	[12]
KAR5585	DMXYN1H	Pulmonary arterial hypertension	BB01.0	Phase 1	[13]
alpha-propyldopacetamide	DMQKMX3	Discovery agent	N.A.	Investigative	[4]
6-fluorotryptophan	DM6YD3U	Discovery agent	N.A.	Investigative	[14]

Drug(s) Targeting L-Tryptophan hydroxylase 2 (TPH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
alpha-propyldopacetamide	DMQKMX3	Discovery agent	N.A.	Investigative	[2]
6-fluorotryptophan	DM6YD3U	Discovery agent	N.A.	Investigative	[14]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
L-Tryptophan hydroxylase 2 (TPH2)	TT3KLDP	TPH2_HUMAN	Inhibitor	[2]
Phenylalanine hydroxylase (PAH)	TTGSVH2	PH4H_HUMAN	Inhibitor	[3]
Tryptophan 5-hydroxylase 1 (TPH1)	TTZSJHV	TPH1_HUMAN	Inhibitor	[4]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5240).
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1242).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1240).
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1241).
• [5] 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
• [6] Induction, titration, and maintenance dosing regimen in a phase 2 study of pegvaliase for control of blood phenylalanine in adults with phenylketonuria.Mol Genet Metab. 2018 Nov;125(3):217-227.
• [7] Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial. Lancet. 2014 Jul 5;384(9937):37-44.
• [8] Clinical pipeline report, company report or official report of Homology Medicines
• [9] ClinicalTrials.gov (NCT04480567) A Phase 1/2 Open-Label, Dose Escalation Study to Determine the Safety and Efficacy of BMN 307, an Adeno-Associated Virus Vector-Mediated Gene Transfer of Human Phenylalanine Hydroxylase in Subjects With Phenylketonuria. U.S.National Institutes of Health.
• [10] Alpha-methylphenylalanine, a new inducer of chronic hyperphenylalaninemia in sucling rats. Science. 1976 Jun 4;192(4243):1007-8.
• [11] Company report of BioMarin
• [12] Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7.
• [13] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [14] (+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Neuropharmacology. 1981 Apr;20(4):335-9.