Details of the Drug-Related molecule(s) Interaction Atlas

Unii-R228S06soh Drug Info

UNII-R228S06SOH; R228S06SOH; AB-22; 1463913-43-0; SCHEMBL15295885; SB19630; N-(2-Chloro-6-propoxypyridin-4-yl)-2-(2-hydroxyethyl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridin-6-yl)hydrazinecarboxamide; Hydrazinecarboxamide, N-(2-chloro-6-propoxy-4-pyridinyl)-2-(1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo(3,4-b)pyridin-6-yl)-2-(2-hydroxyethyl);

Cross-matching ID

PubChem CID

81689736

CAS Number

CAS 1463913-43-0

TTD Drug ID

DMUHSAZ

General Information of Drug (ID: DMUHSAZ)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Sphingosine-1-phosphate receptor 2 (S1PR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiselimod	DMI7CYZ	Ulcerative colitis	DD71	Phase 2	[2]
US8975409, Example 13	DMVB42P	N. A.	N. A.	Patented	[3]
SCHEMBL15295829	DMK0T9E	N. A.	N. A.	Patented	[1]
Jte 013	DMS3HNM	Discovery agent	N.A.	Patented	[1]
US8975409, Example 9(3)	DMJQOAE	N. A.	N. A.	Patented	[3]
US8975409, Comparative compound B	DM4S5DF	N. A.	N. A.	Patented	[3]
AUY954	DMVGIO5	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sphingosine-1-phosphate receptor 2 (S1PR2)	TTVSMOH	S1PR2_HUMAN	Inhibitor	[1]

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References

1	Sphingosine 1-phosphate receptor antagonists. US9663511.
2	Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk. Br J Pharmacol. 2017 Jan;174(1):15-27.
3	Phenyl derivative. US8975409.
4	A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006 Nov;13(11):1227-34.