Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUIFJY)

Drug Name

8-(2-Methyl-cyclohexyloxy)-quinolin-2-ylamine Drug Info

Synonyms

CHEMBL362713; 8-(2-Methyl-cyclohexyloxy)-quinolin-2-ylamine; SCHEMBL5884370

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Melanin-concentrating hormone receptor 1 (MCHR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMS-830216	DMCW71N	Obesity	5B81	Phase 1	[2]
AZD1979	DMQ1OX4	Obesity	5B81	Phase 1	[3]
PMID25522065-Compound-27	DMXN4KB	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-29	DMBNAK9	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-34	DMZDIRQ	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-39	DM5YMQH	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-40	DMCIQ01	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-11	DM410Z6	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-50	DMBWA0V	N. A.	N. A.	Patented	[4]
PMID25522065-Compound-12	DMVKO9C	N. A.	N. A.	Patented	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melanin-concentrating hormone receptor 1 (MCHR1)	TTX4RTB	MCHR1_HUMAN	Inhibitor	[1]

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References

1	Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7.
2	2011 Pipeline of Bristol-Myers Squibb.
3	Phase I clinical trial of AZD1979 for treating obesity. AstraZeneca plc
4	Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207.