Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUKVYL)

Drug Name

EPZ0330456 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Colon cancer	2B90.Z	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

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Drug(s) Targeting Histone-lysine N-methyltransferase SMYD3 (SMYD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EPZ028862	DM2TESM	Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]
EPZ031686	DM8UKL0	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
GSK2807	DMAZROV	Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histone-lysine N-methyltransferase SMYD3 (SMYD3)	TTKLJYX	SMYD3_HUMAN	Inhibitor	[1]

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References

1	Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
2	Therapeutical potential of deregulated lysine methyltransferase SMYD3 as a safe target for novel anticancer agents. Expert Opin Ther Targets. 2017 Feb;21(2):145-157.
3	Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure. 2016 May 3;24(5):774-781.