General Information of Drug (ID: DMULO0V)

Drug Name
TMX-201 Drug Info
Synonyms TLR7-modulating vaccine adjuvant, Telormedix
Indication
Disease Entry ICD 11 Status REF
Autoimmune diabetes 5A10 Investigative [1]
Cross-matching ID
PubChem CID
165437246
TTD Drug ID
DMULO0V

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Toll-like receptor 7 (TLR7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [2]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [3]
ANA773 DMSC8YW Hepatitis C virus infection 1E51.1 Phase 2a [4]
GS-9620 DMG5C8D Hepatitis B virus infection 1E51.0 Phase 2 [5]
IMO-3100 DMM549D Psoriasis vulgaris EA90 Phase 2 [6]
Resiquimod DML6XSP Actinic keratosis EK90.0 Phase 2 [7]
LOXORIBINE DMIV9ZE Immune System disease 4A01-4B41 Phase 2 [8]
GSK2245035 DMBWPZJ Asthma CA23 Phase 2 [9]
AZD-8848 DM0M7QW Allergic rhinitis CA08.0 Phase 2 [10]
Isatoribine DMHOJ8W Hepatitis C virus infection 1E51.1 Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toll-like receptor 7 (TLR7) TTRJ1K4 TLR7_HUMAN Not Available [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1757).
2 Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol. 2009 Nov;129(11):2676-85.
3 TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders. Inflamm Allergy Drug Targets. 2007 Dec;6(4):223-35.
4 Clinical pipeline report, company report or official report of Anadys Pharmaceuticals (2011).
5 Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses. J Pharmacol Exp Ther. 2014 Jan;348(1):96-105.
6 Company report (Iderapharma)
7 TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).Vaccine.2005 Nov 1;23(45):5263-70.
8 The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97.
9 Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement. Clin Pharmacol Ther. 2015 Oct;98(4):369-80.
10 Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis. Respir Res. 2012 Jun 22;13:53.
11 Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):635-40.