Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUQAP7)

Drug Name

29-methylidene-2,3-oxidosqualene Drug Info

Synonyms

29-Mos; 29-Methylidene-2,3-oxidosqualene; 2,2-dimethyl-3-[(3E,7E,11E,15E,19Z)-3,7,12-trimethyl-16-prop-2-enylhenicosa-3,7,11,15,19-pentaenyl]oxirane; AC1O5QC1; (3H)29-Mos; GTPL6719; Oxirane, 3-(16-ethenyl-3,7,12,20-tetramethyl-3,7,11,15,19-heneicosapentaenyl)-2,2-dimethyl-, (S-(all-E))-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6438780
CAS Number: CAS 145919-42-2
TTD Drug ID: DMUQAP7

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZD-9720	DMFV47R	Arteriosclerosis	BD40	Terminated	[3]
BIBB-515	DM6QT9P	Arteriosclerosis	BD40	Terminated	[4]
BIBX-79	DMRXWCO	Arteriosclerosis	BD40	Terminated	[5]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[6]
Lanosterol	DMHN74V	Discovery agent	N.A.	Investigative	[6]
PMID22533316C1	DMYEMWB	Discovery agent	N.A.	Investigative	[7]
PMID22533316C4	DMW3UHO	Discovery agent	N.A.	Investigative	[7]
PMID9003518C4	DMYE64O	Discovery agent	N.A.	Investigative	[2]
Tetradecane	DMK8P61	Discovery agent	N.A.	Investigative	[6]
PMID9003518C3	DM1I578	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lanosterol synthase (LSS)	TT7O8ZA	ERG7_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6719).
2	Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. J Med Chem. 1997 Jan 17;40(2):201-9.
3	Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse. Toxicol Pathol. 2001 Mar-Apr;29(2):174-9.
4	Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. J Lipid Res. 1997 Mar;38(3):564-75.
5	Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. J Lipid Res. 1996 Jan;37(1):148-58.
6	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7	Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells. J Med Chem. 2012 Jun 14;55(11):4990-5002.