Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMURWPH)

Drug Name
ISIS 104838 Drug Info
Indication
Disease Entry ICD 11 Status REF
Crohn disease DD70 Discontinued in Phase 2 [1]
Rheumatoid arthritis FA20 Discontinued in Phase 2 [1]
Therapeutic Class
Antisense
Cross-matching ID
PubChem CID
146028520
TTD Drug ID
DMURWPH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting TNFA messenger RNA (TNF mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PNU-282987 DMGDC36 Schizophrenia 6A20 Terminated [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TNFA messenger RNA (TNF mRNA) TTC97NF TNFA_HUMAN Not Available [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013426)
2 Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
3 Antisense oligonucleotide blockade of tumor necrosis factor-alpha in two murine models of colitis. J Pharmacol Exp Ther. 2003 Jan;304(1):411-24.