Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUVC25)

Drug Name
US9493490, D Drug Info
Synonyms US9493490, Example 4; BDBM258595; US9493490, D; US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-methylbenzo[c][1,2]oxaborol-1(3H)-ol
Cross-matching ID
PubChem CID
90646684
TTD Drug ID
DMUVC25

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Beta-adrenergic receptor kinase 1 (ADRBK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
US9493490, E DMFCIGE N. A. N. A. Patented [1]
US9493490, C DMC1YR5 N. A. N. A. Patented [1]
BDBM50173306 DMSTD28 N. A. N. A. Patented [2]
US9493490, L DMJDTSN N. A. N. A. Patented [1]
PMID24210504C1o DM4LEUT Discovery agent N.A. Investigative [3]
PMID21596927C101 DM7JRHB Discovery agent N.A. Investigative [4]
BetaARKct DMN7DJ5 Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Beta-adrenergic receptor kinase 1 (ADRBK1) TTAZ3MN ARBK1_HUMAN Inhibitor [1]

References

1 Boron-containing small molecules. US9493490.
2 G protein-coupled receptor kinase 2 inhibitors and methods for use of the same. US10023564.
3 Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6711-6.
4 Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors. Mol Pharmacol. 2011 Aug;80(2):294-303.
5 Gene-mediated inhibition of the b-adrenergic receptor kinase: a new therapeutic strategy for heart failure. Minerva Cardioangiol. 2001 Dec;49(6):389-94.