Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUX702)

Drug Name

Fibronectin extra domain A Drug Info

Synonyms

Fibronectin extra domain A (vaccine adjuvant); Fibronectin extra domain A (vaccine adjuvant), Digna Biotech; TLR-4 antagonist (protein recombinant, vaccination), Digna Biotech/University of Navarra

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMUX702

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MPL-containing Pollinex allergy desensitization vaccine	DMXSDJU	Allergy	4A80-4A85	Preregistration	[2]
Cadi-05	DMPTCYB	Prostate cancer	2C82.0	Phase 3	[3]
Resatorvid	DMFMWYC	Sepsis	1G40-1G41	Phase 3	[4]
ERITORAN	DMKQZ0L	Sepsis	1G40-1G41	Phase 3	[5]
G100	DMKHNXA	Non-hodgkin lymphoma	2B33.5	Phase 2	[6]
OM-174	DM2THBX	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
NI-0101	DM31FOP	Autoimmune diabetes	5A10	Phase 1	[1]
GSK1795091	DMC6QE4	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
CRX-675	DMHDSYF	Hepatitis virus infection	1E50-1E51	Phase 1	[1]
CS-4771	DMVDLT4	Sepsis	1G40-1G41	Discontinued in Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Toll-like receptor 4 (TLR4)	TTISGCA	TLR4_HUMAN	Not Available	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1754).
2	Allergy Therapeutics PLC. News Announcement. Allergy Therapeutics. Clinical Trials. Allergy Therapeutics PLC. 11 October 2006.
3	Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716.
4	Clinical pipeline report, company report or official report of Takeda (2009).
5	Small molecule modulators of toll-like receptors. J Med Chem. 2008 Nov 13;51(21):6621-6.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors. BMC Cancer. 2013 Apr 2;13:172.
8	Eritoran insight for influenza treatment. SciBX 6(19); doi:10.1038/scibx.2013.453. May 16 2013