Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV2YDK)

Drug Name

LEISH-F1 Drug Info

Synonyms

LeIF adjuvant, Corixa; Leish-111f; Leishmanial eukaryotic initiation factor, Corixa; Leishmaniasis vaccine (LeIF), Corixa; Leishmaniasis vaccine, Corixa/ Infectious Disease Research Institute; Vaccine (leishmania), Corixa; LeIF enhanced T-cell vaccine, Corixa, Infectious Disease Research Institute

Indication

Disease Entry	ICD 11	Status	REF
Leishmania infection	1F54.0	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMV2YDK

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Cell mediated immunity response (CMIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quattvaxem	DMGAZHU	Bordetella pertussis infection	1C12.0	Approved	[3]
H1N1 pandemic influenza A vaccine	DMFUAXT	Influenza virus infection	1E30-1E32	Approved	[4]
H5N1 influenza vaccine	DMMHYLB	Human immunodeficiency virus infection	1C62	Approved	[5]
Live attenuated influenza vaccine	DMX9PIA	Influenza virus infection	1E30-1E32	Approved	[6]
HEV-239	DMGUC9T	Hepatitis E virus infection	1E50.4	Approved	[7]
Polyoxidonium	DMJAOT1	Infectious disease	1A00-CA43.1	Approved	[8]
GSK2592984A	DM8QB0T	Influenza virus infection	1E30-1E32	Approved	[9]
Focetria A(H1N1)	DM2PSBE	Influenza virus infection	1E30-1E32	Approved	[10]
Fendrix	DM0LRU9	Hepatitis B virus infection	1E51.0	Approved	[11]
Arepanrix	DMVMY7K	Influenza virus infection	1E30-1E32	Approved	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cell mediated immunity response (CMIR)	TT3J5ZI	NOUNIPROTAC	Not Available	[2]

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References

1	An overview on Leishmania vaccines: A narrative review article. Vet Res Forum. 2015 Winter;6(1):1-7.
2	A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine for use in the prevention of visceral leishmaniasis. Vaccine. 2011 Apr 27;29(19):3531-7.
3	Double-blind study comparing the immunogenicity of a licensed DTwPHib-CRM197 conjugate vaccine (Quattvaxem) with three investigational, liquid formulations using lower doses of Hib-CRM197 conjugate. Vaccine. 2005 Feb 25;23(14):1715-9.
4	How Influenza (Flu) Vaccines Are Made. FLU.gov. 2014.
5	Comparative clinical trial of vaccines against avian influenza. Zh Mikrobiol Epidemiol Immunobiol. 2007 May-Jun;(3):10-6.
6	Flu myths: dispelling the myths associated with live attenuated influenza vaccine. Mayo Clin Proc. 2008 Jan;83(1):77-84.
7	The development of a recombinant hepatitis E vaccine HEV 239. Hum Vaccin Immunother. 2015;11(4):908-14.
8	Effect of polyoxidonium on the phagocytic activity of human peripheral blood leukocytes. Russ J Immunol. 2003 Apr;8(1):53-60.
9	Anti-influenza agents from Traditional Chinese Medicine. Nat Prod Rep. 2010 Jan;27(12):1758-80.
10	Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study. BMJ. 2013 Feb 4;346:f393.
11	Revaccination with Fendrix or HBVaxPro results in better response rates than does revaccination with three doses of Engerix-B in previous non-responders. Vaccine. 2012 Nov 6;30(48):6734-7.
12	Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development. Brain Behav Immun. 2015 Jul;47:44-57.