Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV486E)

Drug Name

polyIC Drug Info

Synonyms

poly(I:C); polyinosine:polycytidylic acid; polyinosine-polycytosine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Toll-like receptor 3 (TLR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rintatolimod	DMYX7VI	Human immunodeficiency virus infection	1C62	Phase 3	[3]
Poly-ICLC	DM2570B	Glioblastoma multiforme	2A00.0	Phase 2	[4]
BCG65-E7	DMAMFXC	Anal intraepithelial neoplasia	2E92.5	Discontinued in Phase 3	[5]
IPH-3102	DMY3BMC	Solid tumour/cancer	2A00-2F9Z	Terminated	[6]
Poly IC-poly arginine	DMXA4HY	Keratosis	ED56	Investigative	[7]
Anti-TLR3 mabs	DMN76A4	Autoimmune diabetes	5A10	Investigative	[7]
Poly-ICR	DMUMJ7B	Keratosis	ED56	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5047).
2	Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001 Oct 18;413(6857):732-8.
3	A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome. PLoS One. 2012;7(3):e31334.
4	Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med. 2007 Feb 12;5:10.
5	Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia. Gynecol Oncol. 2010 Feb;116(2):208-12.
6	Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1753).