Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV6DAO)

Drug Name

abnormal cannabidiol Drug Info

Synonyms

Abn-CBD; CAY10429

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting N-arachidonyl glycine receptor (GPR18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
N-arachidonoylglycine	DM85RJ1	Discovery agent	N.A.	Investigative	[4]
arachidonylcyclopropylamide	DMZM5KE	Discovery agent	N.A.	Investigative	[3]
O-1602	DM9VISB	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting G-protein coupled receptor 55 (GPR55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[2]
BIO-017	DMYHK3Y	Angelman syndrome	LD90.0	Phase 1	[5]
N-oleoylethanolamide	DMJQ4L7	Discovery agent	N.A.	Investigative	[2]
[3H]CP55940	DMU7FC5	Discovery agent	N.A.	Investigative	[2]
lysophosphatidylinositol	DMETM3R	Discovery agent	N.A.	Investigative	[6]
O-1602	DM9VISB	Discovery agent	N.A.	Investigative	[7]
O-arachidonoyl ethanolamine	DML0P72	Discovery agent	N.A.	Investigative	[2]
CID1172084	DMK6YOP	Discovery agent	N.A.	Investigative	[8]
CID16020046	DMLWZRT	Discovery agent	N.A.	Investigative	[9]
2-arachidonyl glyceryl ether	DM2H8TV	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled receptor 55 (GPR55)	TTNET8J	GPR55_HUMAN	Agonist	[2]
N-arachidonyl glycine receptor (GPR18)	TTSLJAR	GPR18_HUMAN	Agonist	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5526).
2	The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007 Dec;152(7):1092-101.
3	Delta(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol. 2012 Apr;165(8):2414-24.
4	Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. Biochem Biophys Res Commun. 2006 Sep 1;347(3):827-32.
5	Clinical pipeline report, company report or official report of Biom Therapeutics
6	Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609.
7	International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB and CB Pharmacol Rev. 2010 Dec;62(4):588-631.
8	Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2011 Jun 28;50(25):5633-47.
9	A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J Pharmacol Exp Ther. 2013 Jul;346(1):54-66.