General Information of Drug (ID: DMVCA06)

Drug Name
AMG 609 Drug Info
Indication
Disease Entry ICD 11 Status REF
Non-alcoholic steatohepatitis DB92.1 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMVCA06

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ION839 DMWZT3N Non-alcoholic steatohepatitis DB92.1 Phase 2 [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 messenger RNA (PNPLA3 mRNA) TTEUAEH PLPL3_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT04857606) A Phase 1, Randomized, Double-blind, Placebo-controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 609 in Subjects With Non-alcoholic Fatty Liver Disease. U.S.National Institutes of Health.
2 Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease. Metabolism. 2022 Jan;126:154925.
3 Clinical pipeline report, company report or official report of Ionis