Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVGITD)

Drug Name

Ro48-8071 Drug Info

Synonyms

[4-({6-[Allyl(methyl)amino]hexyl}oxy)-2-fluorophenyl](4-bromophenyl)methanone; Ro 48-8071; 161582-11-2; Ro-48-8071; [4-({6-[allyl(methyl)amino]hexyl}oxy)-2-fluorophenyl](4-bromophenyl)methanone; CHEMBL304858; R048-8071; R71; 1gsz; (4-bromophenyl)[2-fluoro-4-({6-[methyl(prop-2-en-1-yl)amino]hexyl}oxy)phenyl]methanone; C23H27BRFNO2; {4-[6-(Allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-(4-bromo-phenyl)-methanone; (4-((6-(Allyl(methyl)amino)hexyl)oxy)-2-fluorophenyl)(4-bromophenyl)methanone; [4-[6-(allyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl]-(4-bromo-phenyl)-methanone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1949
ChEBI ID: CHEBI:101064
CAS Number: CAS 161582-11-2
TTD Drug ID: DMVGITD

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZD-9720	DMFV47R	Arteriosclerosis	BD40	Terminated	[2]
BIBB-515	DM6QT9P	Arteriosclerosis	BD40	Terminated	[3]
BIBX-79	DMRXWCO	Arteriosclerosis	BD40	Terminated	[4]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[1]
Lanosterol	DMHN74V	Discovery agent	N.A.	Investigative	[1]
PMID22533316C1	DMYEMWB	Discovery agent	N.A.	Investigative	[5]
PMID22533316C4	DMW3UHO	Discovery agent	N.A.	Investigative	[5]
PMID9003518C4	DMYE64O	Discovery agent	N.A.	Investigative	[6]
29-methylidene-2,3-oxidosqualene	DMUQAP7	Discovery agent	N.A.	Investigative	[6]
Tetradecane	DMK8P61	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lanosterol synthase (LSS)	TT7O8ZA	ERG7_HUMAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse. Toxicol Pathol. 2001 Mar-Apr;29(2):174-9.
3	Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. J Lipid Res. 1997 Mar;38(3):564-75.
4	Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. J Lipid Res. 1996 Jan;37(1):148-58.
5	Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells. J Med Chem. 2012 Jun 14;55(11):4990-5002.
6	Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. J Med Chem. 1997 Jan 17;40(2):201-9.