Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVPAZ7)

Drug Name

BAY1143572 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Positive transcription elongation factor b (P-TEFb)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY1251152	DMCJNRL	Haematological malignancy	2B33.Y	Phase 1	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Positive transcription elongation factor b (P-TEFb)	TTQ7ABG	CDK9_HUMAN-CCNT1_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT02345382) Phase I Dose Escalation of BAY1143572 in Subjects With Acute Leukemia. U.S. National Institutes of Health.
2	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)